NJH-2-057
NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.
Product Specifications
CAS Number
[2858812-70-9]
Product Name Alternative
T-Type calcium channel inhibitor,(Z)-SU4321
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/njh-2-057.html
Purity
98.87
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N1CC(N(CC1)C2=CC=C(CCC(NCCCCCNC(C3=CC=CC(C4=NC(NC(C5(CC5)C6=CC=C7OC(F)(OC7=C6)F)=O)=CC=C4C)=C3)=O)=O)O2)=O)C=C
Molecular Formula
C43H44F2N6O8
Molecular Weight
810.84
References & Citations
[1]Henning NJ, et al. Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization. 2021 May 03.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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