KIN101

KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses[1][2].

Product Specifications

CAS Number

[610753-87-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dengue Virus; Flavivirus; HCV; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/kin101.html

Purity

99.44

Solubility

DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C(C2=CC=C(Br)C=C2)=COC3=CC(OS(=O)(C)=O)=CC=C13

Molecular Formula

C16H11BrO5S

Molecular Weight

395.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Shawn P. Iadonato, et al. Anti-viral compounds, pharmaceutical compositions and methods of use thereof. US20160122312A1.|[2]Bedard KM, et al. Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses. J Virol. 2012 Jul;86 (13) :7334-44.