Ganglioside GD3 (diammonium)

Ganglioside GD3 diammonium is an acidic glycosphingolipid. Ganglioside GD3 diammonium inhibits the proliferation of cancer cells, affects the opening of the mitochondrial permeability transition pore (PTPC), induces apoptosis and activates caspase family. Ganglioside GD3 diammonium can be used in research about cancer and neurodegenerative diseases[1].

Product Specifications

CAS Number

[1246353-20-7]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ganglioside-gd3-diammonium.html

Purity

98.0

Smiles

OC([C@](O[C@@]([C@@H]1NC(C)=O)([H])[C@H](O)[C@@H](CO)O[C@@](O[C@@]([C@@H]2NC(C)=O)([H])[C@H](O)[C@H](O)CO)(C[C@@H]2O)C(O)=O)(C[C@@H]1O)O[C@@H]([C@H]([C@H]3CO)O)[C@H]([C@@H](O3)O[C@@H]([C@@H]([C@H]4O)O)[C@H](O[C@H]4OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC)=O)CO)O)=O.N.N

Molecular Formula

C70H131N5O29

Molecular Weight

1506.81

References & Citations

[1]Malisan F, et al., GD3 ganglioside and apoptosis. Biochim Biophys Acta. 2002 Dec 30;1585 (2-3) :179-87.|[2]Kazunori Hamamura, et al. Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells. Proc Natl Acad Sci U S A. 2005 Aug 2;102 (31) :11041-6.