Ku-80 rabbit pAb
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V (D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
Gene ID
7520
UniProt
P13010
Cellular Locus
Nucleus. Nucleus, nucleolus. Chromosome.
Host
Rabbit
Species Reactivity
Human,Rat,Mouse,
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human Ku-80
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
IHC, IF, WB
Validated Applications
IHC,IF,WB
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
IHC-p 1:50-200, WB 1:500-2000
Molecular Weight
82kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES15227-1.pdf
Observed Molecular Weight
82 kD
Subcellular Location
Nucleus . Nucleus, nucleolus . Chromosome .
Other Product Names
Gene ID (Human)
7520
SwissProt (Human)
P13010
Available Sizes
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