E-64-c

<strong>E-64-c</strong> <strong>Catalog number:</strong> MDP0688 <strong>CAS Number: </strong>131438-79-4 <strong>Sequence: </strong>[(2S,3S)-3-Carboxyoxirane-2-carbonyl]-L-leucine (3-methylbutyl)amide <strong>Amount:</strong> 1 mg <strong>Molecular Weight:</strong> 314 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Yamamoto D, Matsumoto K, Ohishi H, Ishida T, Inoue M, Kitamura K, Mizuno H. Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution J Biol Chem. 1991 Aug 5;266(22):14771-7. 2: Hashida S, Towatari T, Kominami E, Katunuma N. Inhibitions by E-64 derivatives of rat liver cathepsin B and cathepsin L in vitro and in vivo J Biochem. 1980 Dec;88(6):1805-11. 3: Matsumoto K, Yamamoto D, Ohishi H, Tomoo K, Ishida T, Inoue M, Sadatome T, Kitamura K, Mizuno H. Mode of binding of E-64-c, a potent thiol protease inhibitor, to papain as determined by X-ray crystal analysis of the complex FEBS Lett. 1989 Mar 13;245(1-2):177-80. 4: Ishiura S, Nonaka I, Sugita H. Suppression of calcium-induced removal of the Z-line by a thiol-protease inhibitor, E-64-c J Biochem. 1981 Jul;90(1):283-5. 5: Matsumoto K, Mizoue K, Kitamura K, Tse WC, Huber CP, Ishida T. Structural basis of inhibition of cysteine proteases by E-64 and its derivatives Biopolymers. 1999;51(1):99-107. 6: Tamai M, Matsumoto K, Omura S, Koyama I, Ozawa Y, Hanada K. In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64 J Pharmacobiodyn. 1986 Aug;9(8):672-7. 7: Radzey H, Rethmeier M, Klimpel D, Grundhuber M, Sommerhoff CP, Schaschke N. E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors ChemMedChem. 2013 Aug;8(8):1314-21. 8: Ishiura S, Hanada K, Tamai M, Kashiwagi K, Sugita H. The effect of an in vivo-injected thiol protease inhibitor, E-64-c, on the calcium-induced degeneration of myofilaments J Biochem. 1981 Nov;90(5):1557-60. 9: Noda T, Isogai K, Katunuma N, Tarumoto Y, Ohzeki M. Effects of cathepsin B, H, and D in pectoral muscle of dystrophic chickens (line 413) of in vivo administration of E-64-c (N-[N-(L-3-transcarboxyoxirane-2-carbonyl)-L-leucyl]-3-methyl-butylamine) J Biochem. 1981 Sep;90(3):893-6. <a href="https://pubmed.ncbi.nlm.nih.gov/7287681">10: Tamai M, Hanada K, Adachi T, Oguma K, Kashiwagi K, Omura S, Ohzeki M. Papain inhibitions by optically active E-64 analogs J Biochem. 1981 Jul;90(1):255-7. </a> <br><strong>Products Related to E-64-c can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>