MGluR2 antagonist 1
MGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1].
Product Specifications
CAS Number
1432728-49-8
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mglur2-antagonist-1.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC(C1=NC2=CC(CN3C(CCC3=O)=O)=CC=C2C(C4=CC=C(F)C=C4)=C1)=O
Molecular Formula
C21H16FN3O3
Molecular Weight
377.37
References & Citations
[1]Youheng Shu, et al. Discovery of 4-arylquinoline-2-carboxamides, Highly Potent and Selective Class of mGluR2 Negative Allosteric Modulators: From HTS to Activity in Animal Models. Bioorg Med Chem Lett. 2020 May 1;30 (9) :127066.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP324784M 100 µg
IL36 gamma (IL36G) (NM_019618) Human Recombinant Protein
Sign In for Pricing
View Details 
