MGluR2 antagonist 1
MGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1].
Product Specifications
CAS Number
1432728-49-8
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mglur2-antagonist-1.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC(C1=NC2=CC(CN3C(CCC3=O)=O)=CC=C2C(C4=CC=C(F)C=C4)=C1)=O
Molecular Formula
C21H16FN3O3
Molecular Weight
377.37
References & Citations
[1]Youheng Shu, et al. Discovery of 4-arylquinoline-2-carboxamides, Highly Potent and Selective Class of mGluR2 Negative Allosteric Modulators: From HTS to Activity in Animal Models. Bioorg Med Chem Lett. 2020 May 1;30 (9) :127066.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2
Available Sizes
Frequently Asked Questions
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