1-Stearoyl-sn-glycero-3-phosphocholine

1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells[1].

Product Specifications

CAS Number

[19420-57-6]

Product Name Alternative

18:0 Lyso-PC; LPC (18:0)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; HDAC; STAT

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-stearoyl-sn-glycero-3-phosphocholine.html

Purity

99.53

Solubility

Ethanol : 12.5 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCCCCCC(OC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O)=O

Molecular Formula

C26H54NO7P

Molecular Weight

523.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Jung JH, et al. Inactivation of HDAC3 and STAT3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia K562 cells. Cell Biochem Biophys. 2013;67 (3) :1379-89.