Caftaric acid

Caftaric acid (trans-Caftaric acid) is a polyphenolic antidiuretic, antioxidant and anti-apoptotic agent that can be hydrolyzed by intestinal microbial esterases. Caftaric acid exerts its antioxidant and potential anti-inflammatory effects mainly through intestinal microbial metabolism. Caftaric acid can reduce renal damage, restore electrolyte balance, renal function indicators and antioxidant enzyme activities in a rat albinism model, and further exert anti-oxidative stress and anti-inflammatory activities[1][2][3].

Product Specifications

CAS Number

[67879-58-7]

Product Name Alternative

Trans-Caftaric acid

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Others

Type

Natural Products

Related Pathways

Others

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Caftaric-acid.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(O)[C@H](OC(/C=C/C1=CC=C(O)C(O)=C1)=O)[C@@H](O)C(O)=O

Molecular Formula

C13H12O9

Molecular Weight

312.23

Precautions

H315, H319

References & Citations

[1]Gonthier MP, et al. Microbial metabolism of caffeic acid and its esters chlorogenic and caftaric acids by human faecal microbiota in vitro. Biomed Pharmacother. 2006 Nov;60 (9) :536-40.|[2]Koriem KMM, Arbid MS. Role of caftaric acid in lead-associated nephrotoxicity in rats via antidiuretic, antioxidant and anti-apoptotic activities. J Complement Integr Med. 2017 Nov 17;15 (2) :/j/jcim.2018.15.issue-2/jcim-2017-0024/jcim-2017-0024.xml.|[3]Ekinci Akdemir FN, Güler MC, Eraslan E, Tanyeli A, Yildirim S. Caftaric acid attenuates kidney and remote organ damage induced by renal ischemia-reperfusion injury. Sci Rep. 2024 Dec 28;14 (1) :31385.