Bleselumab
Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb) . Bleselumab binds to human CD40 with high affinity (Kd: 0.24 nM) . Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection[1].
Product Specifications
CAS Number
1453067-91-8
Product Name Alternative
ASKP 1240
UNSPSC
12352203
Target
TNF Receptor
Type
Inhibitory Antibodies
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bleselumab.html
Purity
98.97
Solubility
10 mM in DMSO
Smiles
[Bleselumab]
Molecular Weight
(144.6 kDa)
References & Citations
[1]Harland RC, et al. Efficacy and safety of bleselumab in kidney transplant recipients: A phase 2, randomized, open-label, noninferiority study. Am J Transplant. 2020 Jan;20 (1) :159-171. |[2]Okimura K, et al. Characterization of ASKP1240, a fully human antibody targeting human CD40 with potent immunosuppressive effects. Am J Transplant. 2014 Jun;14 (6) :1290-9. |[3]Song L, et al. Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys. Transplantation. 2014 Aug 15;98 (3) :267-76.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2
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Frequently Asked Questions
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