ALOX15-IN-1

ALOX15-IN-1 (compound 8b) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 0.04 and 2.06 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1].

Product Specifications

CAS Number

[2764818-24-6]

UNSPSC

12352005

Target

Lipoxygenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/alox15-in-1.html

Purity

98.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(NC1=C(C=CC(C2=CC3=C(C=CC=C3)N2)=C1)OC)(NC(OCCCCCCCC)=O)=O

Molecular Formula

C24H31N3O5S

Molecular Weight

473.59

References & Citations

[1]Golovanov A, et al. N-Substituted 5- (1H-Indol-2-yl) -2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action. J Med Chem. 2022;65 (3) :1979-1995.