Oxazolone
Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins[1].
Product Specifications
CAS Number
[15646-46-5]
UNSPSC
12352005
Hazard Statement
H317
Target
Interleukin Related; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/oxazolone.html
Purity
98.0
Solubility
50% Ethanol in Water : 10 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC(C1=CC=CC=C1)=N/2)C2=C/OCC
Molecular Formula
C12H11NO3
Molecular Weight
217.22
Precautions
H317
References & Citations
[1]Weigmann B, et al. Oxazolone-Induced Colitis as a Model of Th2 Immune Responses in the Intestinal Mucosa. Methods Mol Biol. 2016;1422:253-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-13; IL-4; TNFRSF1A/CD120a
Available Sizes
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