(±) 15-HEDE

(±) 15-HEDE is a racemic mixture of the monohydroxy fatty acids 15 (R) -HEDE and 15 (S) -HEDE. 15-HEDE is formed from eicosadienoic acid in macrophages. It inhibits 5-lipoxygenase (5-LO; IC50=35 μM) .

Product Specifications

CAS Number

[77159-57-0]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Lipoxygenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/racemic-15-hede.html

Smiles

CCCCCC(O)/C=C/C=C\CCCCCCCCCC(O)=O

Molecular Formula

C20H36O3

Molecular Weight

324.50

Precautions

P261-P280-P302+P352

References & Citations

[1]Haviv, et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J. Med. Chem. 30 (2), 254-263 (1987) .