(±) 15-HEDE
(±) 15-HEDE is a racemic mixture of the monohydroxy fatty acids 15 (R) -HEDE and 15 (S) -HEDE. 15-HEDE is formed from eicosadienoic acid in macrophages. It inhibits 5-lipoxygenase (5-LO; IC50=35 μM) .
Product Specifications
CAS Number
[77159-57-0]
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/racemic-15-hede.html
Smiles
CCCCCC(O)/C=C/C=C\CCCCCCCCCC(O)=O
Molecular Formula
C20H36O3
Molecular Weight
324.50
Precautions
P261-P280-P302+P352
References & Citations
[1]Haviv, et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J. Med. Chem. 30 (2), 254-263 (1987) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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