7-epi-Taxol

7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

Product Specifications

CAS Number

[105454-04-4]

Product Name Alternative

7-epi-Paclitaxel

UNSPSC

12352005

Hazard Statement

H341, H360

Target

Microtubule/Tubulin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7-epi-Taxol.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H]1C[C@]2([H])[C@](CO2)(OC(C)=O)[C@]3([H])[C@]1(C)C([C@H](OC(C)=O)C4=C(C)[C@@H](OC([C@@H]([C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)O)=O)C[C@]([C@H]3OC(C7=CC=CC=C7)=O)(O)C4(C)C)=O

Molecular Formula

C47H51NO14

Molecular Weight

853.91

Precautions

H341, H360

References & Citations

[1]Royer I, et al. Paclitaxel metabolites in human plasma and urine: identification of 6 alpha-hydroxytaxol, 7-epitaxol and taxol hydrolysis products using liquid chromatography/atmospheric-pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 1995;9 (6) :495-502.|[2]Ringel I, et al. Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium. J Pharmacol Exp Ther. 1987 Aug;242 (2) :692-8.