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Lobetyol

Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity[1][2]. Lobetyol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

136171-87-4

Product Name Alternative

Mutagenic Impurity of Tenofovir Disoproxil; Tenofovir Impurity 2,Methyl (2E,4E,6Z)-decatrienoate

UNSPSC

12352211

Target

Apoptosis; Bcl-2 Family; MDM-2/p53

Type

Natural Products

Related Pathways

Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lobetyol.html

Solubility

10 mM in DMSO

Smiles

C/C=C/C#CC#CC(O)C(O)/C=C/CCCO

Molecular Formula

C14H18O3

Molecular Weight

234.29

References & Citations

[1]Shen J, et al. Lobetyol activate MAPK pathways associated with G1/S cell cycle arrest and apoptosis in MKN45 cells in vitro and in vivo. Biomed Pharmacother. 2016 Jul;81:120-127.|[2]Xie Q, et al. The in vitro/in vivo metabolic pathways analysis of lobetyol, lobetyolin, and lobetyolinin, three polyacetylenes from Codonopsis Radix, by UHPLC-Q/TOF-MS and UHPLC-MS/MS. J Pharm Biomed Anal. 2023 Jan 20;223:115140.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Bax; Bcl-2

Available Sizes

Frequently Asked Questions

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