H-Glu (OtBu) -OtBu (hydrochloride)

H-Glu (OtBu) -OtBu hydrochloride is a key intermediate that can be used to synthesize prostate-specific membrane antigen (PSMA) targeting probes. H-Glu (OtBu) -OtBu hydrochloride can reduce nonspecific background binding through negatively charged linkers, improve tumor/background contrast, and can be used in prostate cancer PET/SPECT imaging studies[1].

Product Specifications

CAS Number

[32677-01-3]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/h-glu-otbu-otbu-hydrochloride.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N[C@@H](CCC(OC(C)(C)C)=O)C(OC(C)(C)C)=O.[H]Cl

Molecular Formula

C13H26ClNO4

Molecular Weight

295.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Huang SS, et al. Improving the biodistribution of PSMA-targeting tracers with a highly negatively charged linker. Prostate. 2014 May;74 (7) :702-13.