TrkA-IN-1
TrkA-IN-1 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 of 99 nM in a cell-based assay. TrkA-IN-1 has analgesic activity[1].
Product Specifications
CAS Number
[1680179-43-4]
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trka-in-1.html
Purity
96.46
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=CN=C(C)N=C1C2=CC=CC=C2)NC3C4=C(C5=C3C=CC=C5)C=CC=C4
Molecular Formula
C25H20N4O
Molecular Weight
392.45
References & Citations
[1]Su HP , et al. Structural characterization of nonactive site, TrkA-selective kinase inhibitors. Proc Natl Acad Sci U S A. 2017 Jan 17;114 (3) :E297-E306.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkB; TrkC
Available Sizes
Curated Selection
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