LY 3000328

LY 3000328 (Z-FL-COCHO) is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively.

Product Specifications

CAS Number

[1373215-15-6]

Product Name Alternative

Z-FL-COCHO

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/LY-3000328.html

Concentration

10mM

Purity

99.50

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(C1=CC=C(F)C=C1)N[C@@H]2[C@@H](OC(NC)=O)COC3=CC=C(N4CCN(C5COC5)CC4)C=C32

Molecular Formula

C25H29FN4O5

Molecular Weight

484.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Jadhav PK, et al. Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. ACS Med Chem Lett. 2014 Aug 27;5 (10) :1138-42.|[2]Payne CD, et al. Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects. Br J Clin Pharmacol. 2014 Dec;78 (6) :1334-42.