Levamlodipine

Levamlodipine ((S) -Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina[1].

Product Specifications

CAS Number

[103129-82-4]

Product Name Alternative

(S) -Amlodipine; Levoamlodipine

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Calcium Channel; SOD

Type

Reference compound

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/levamlodipine.html

Purity

98.53

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC=C2Cl)OCC

Molecular Formula

C20H25ClN2O5

Molecular Weight

408.88

Precautions

H315, H319, H320

References & Citations

[1]Jain R, et al. Polyaniline-graphene oxide nanocomposite sensor for quantification of calcium channel blocker levamlodipine. Mater Sci Eng C Mater Biol Appl. 2016 Aug 1;65:205-14.|[2]Rong H, et al. [Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 May;37 (5) :458-62.|[3]Yang YL, et al. Synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats. CNS Neurosci Ther. 2012 Jun;18 (6) :471-4.|[4]Lee YJ, et al. Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress. J Neurochem. 2011 Dec;119 (6) :1262-70.