NVS MLLT-1

NVS MLLT-1 (compound 3), a chemical probe, is a potent and selective MLLT1 inhibitor with Kd values of 0.18 μM, 0.24 μM, and 0.22 μM for wild-type, T1 mutants, and T3 mutants, respectively[1][2].

Product Specifications

CAS Number

[2561471-13-2]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nvs-mllt-1.html

Purity

99.3

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(C=NC=C2)C=C1)NC3=CC=C4C(NC(CN5[C@H](CCC5)C)=N4)=C3

Molecular Formula

C23H23N5O

Molecular Weight

385.46

References & Citations

[1]Ni X, et al. Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. ACS Chem Biol. 2021 Apr 16;16 (4) :571-578.|[2]Lee J, et al. The Promise and Peril of Chemical Probe Negative Controls. ACS Chem Biol. 2021 Apr 16;16 (4) :579-585.