NVS MLLT-1
Product Specifications
UNSPSC Description
NVS MLLT-1 (compound 3) is a potent and selective MLLT1 inhibitor with Kd values of 0.18 µM, 0.24 µM, and 0.22 µM for wild-type, T1 mutants, and T3 mutants, respectively[1][2].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nvs-mllt-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(C=NC=C2)C=C1)NC3=CC=C4C(NC(CN5[C@H](CCC5)C)=N4)=C3
Molecular Weight
385.46
References & Citations
[1]Ni X, et al. Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. ACS Chem Biol. 2021 Apr 16;16(4):571-578.|[2]Lee J, et al. The Promise and Peril of Chemical Probe Negative Controls. ACS Chem Biol. 2021 Apr 16;16(4):579-585.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160287/NVS-MLLT-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160287/
Clinical Information
No Development Reported
CAS Number
2561471-13-2
Available Sizes
Curated Selection
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