NNMT-IN-4
Product Specifications
UNSPSC Description
NNMT-IN-4 (compound 38) is a selective, uncompetitive and membrane permeability nicotinamide N-methyltransferase (NNMT) inhibitor with IC50 values of 42 and 38 nM in vitro biochemical and cell-based assays, respectively. NNMT-IN-4 shows favorable PK/PD and safety profiles as well as excellent oral bioavailability and pharmaceutical properties. NNMT-IN-4 can be used as a vivo chemical probe of NNMT[1].
Target Antigen
Fluorescent Dye
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nnmt-in-4.html
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C[C@@H]1CC2=C(N1)N=CC(C(N)=O)=C2
Molecular Weight
177.20
References & Citations
[1]Barrows RD, et al. Potent Uncompetitive Inhibitors of Nicotinamide N-Methyltransferase (NNMT) as In Vivo Chemical Probes. J Med Chem. 2022 Nov 10;65(21):14642-14654.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151813/NNMT-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151813/NNMT-IN-4-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2947393-64-6
Available Sizes
Curated Selection
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