NNMT-IN-4

NNMT-IN-4 (compound 38) is a selective, uncompetitive and membrane permeability nicotinamide N-methyltransferase (NNMT) inhibitor with IC50 values of 42 and 38 nM in vitro biochemical and cell-based assays, respectively. NNMT-IN-4 shows favorable PK/PD and safety profiles as well as excellent oral bioavailability and pharmaceutical properties. NNMT-IN-4 can be used as a vivo chemical probe of NNMT[1].

Product Specifications

CAS Number

[2947393-64-6]

UNSPSC

12352005

Target

Fluorescent Dye

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nnmt-in-4.html

Purity

99.35

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@H]1CC2=C(N1)N=CC(C(N)=O)=C2

Molecular Formula

C9H11N3O

Molecular Weight

177.20

References & Citations

[1]Barrows RD, et al. Potent Uncompetitive Inhibitors of Nicotinamide N-Methyltransferase (NNMT) as In Vivo Chemical Probes. J Med Chem. 2022 Nov 10;65 (21) :14642-14654.