PF-04418948
PF-04418948, a chemical probe, is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM[1].
Product Specifications
CAS Number
1078166-57-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/PF-04418948.html
Purity
99.40
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1(COC2=CC=C3C=C(OC)C=CC3=C2)CN(C(C4=CC=C(F)C=C4)=O)C1)O
Molecular Formula
C23H20FNO5
Molecular Weight
409.41
Precautions
H302, H315, H319, H335
References & Citations
[1]af Forselles KJ, et al. In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist. Br J Pharmacol. 2011 Dec;164 (7) :1847-1856.|[2]Birrell MA, et al. Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor. Br J Pharmacol. 2013 Jan;168 (1) :129-138.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
EP
Available Sizes
Frequently Asked Questions
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