DS21150768
DS21150768 is a potent, orally active HPK1 inhibitor. DS21150768 shows potent activity to enhance T-cell function. DS21150768 has anticancer effects[1].
Product Specifications
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds21150768.html
Purity
99.26
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC=C(N2C(C(C(NC3=CC=C(C4=C(N)N=CC(C5=CC(C)=NC(C)=C5)=C4)C=C3)=O)=C(NCC6(C7)CC7(F)C6)C=C2)=O)C=C1
Molecular Formula
C36H32F2N6O2
Molecular Weight
618.68
References & Citations
[1]Genzui Setsu, et al. Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models. Eur J Pharmacol. 2023 Nov 8:961:176184.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K1/HPK1
Available Sizes
Curated Selection
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