Sodium Camptothecin

Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA[1][2].

Product Specifications

CAS Number

[25387-67-1]

UNSPSC

12352005

Hazard Statement

H301

Target

DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/sodium-camptothecin.html

Purity

95.0

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C1N2C(C3=NC4=CC=CC=C4C=C3C2)=CC([C@](CC)(O)C(O[Na])=O)=C1CO

Molecular Formula

C20H17N2NaO5

Molecular Weight

388.35

Precautions

H301

References & Citations

[1]R S Wu, et al. Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis. Proc Natl Acad Sci U S A. 1971 Dec;68 (12) :3009-14.|[2]M S Horwitz, et al. Camptothecin: mechanism of inhibition of adenovirus formation. Virology. 1972 Jun;48 (3) :690-8