Otenabant

Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.

Product Specifications

CAS Number

[686344-29-6]

Product Name Alternative

CP-945598

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Otenabant.html

Purity

99.23

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=CC=C1C2=NC3=C(N4CCC(NCC)(C(N)=O)CC4)N=CN=C3N2C5=CC=C(Cl)C=C5

Molecular Formula

C25H25Cl2N7O

Molecular Weight

510.42

Precautions

H302, H315, H319, H335

References & Citations

[1]John R. Hadcock, et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochemical and Biophysical Research Communications, 2010; 394;366-371.|[2]Griffith DA, et al. Discovery of 1-[9- (4-chlorophenyl) -8- (2-chlorophenyl) - 9H-purin-6-yl] -4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. JMedChem. 2009 ;5