Trans-R-138727

Trans-R-138727 is the trans isomer of R-138727 (HY-123669) . R-138727 is the active metabolite of the antiplatelet agent Prasugrel (HY-15284) . R-138727 is an irreversible inhibitor for the platelet receptor P2Y12, and inhibits ADP-induced platelet activation and aggregation[1].

Product Specifications

CAS Number

[239466-74-1]

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trans-r-138727.html

Purity

98.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C1CN(C(C2=CC=CC=C2F)C(C3CC3)=O)CCC\1S

Molecular Formula

C18H20FNO3S

Molecular Weight

349.42

References & Citations

[1]Hasegawa M, et al. Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor. Thromb Haemost. 2005 Sep;94 (3) :593-8.