7β,16α-Dihydroxybufalin

7β,16α-Dihydroxybufalin is a dihydroxylated derivative of bufalin, which exhibits cytotoxicities against cancer cell lines[1][2].

Product Specifications

CAS Number

773133-78-1

UNSPSC

12352211

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7β-16α-dihydroxybufalin.html

Smiles

O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(C=C4)=COC4=O)[C@@H](C2)O)C)([H])[C@@]5([C@](C[C@H](CC5)O)([H])C[C@@H]3O)C

Molecular Formula

C24H34O6

Molecular Weight

418.52

References & Citations

[1]Ye M, et al. Novel cytotoxic bufadienolides derived from bufalin by microbial hydroxylation and their structure-activity relationships. J Steroid Biochem Mol Biol. 2004 Jun;91 (1-2) :87-98.|[2]Li K, et al. Enzymatic synthesis of bufadienolide O‐glycosides as potent antitumor agents using a microbial glycosyltransferase[J]. Advanced Synthesis & Catalysis, 2017, 359 (21) : 3765-3772.