CHIR-124
CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM.
Product Specifications
CAS Number
405168-58-3
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Checkpoint Kinase (Chk) ; FLT3; PDGFR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CHIR-124.html
Purity
99.05
Solubility
DMSO : 7.14 mg/mL (ultrasonic)
Smiles
ClC1=CC2=C(NC(C(C3=NC4=C(C=CC=C4)N3)=C2N[C@@H]5CN6CCC5CC6)=O)C=C1
Molecular Formula
C23H22ClN5O
Molecular Weight
419.91
Precautions
H302
References & Citations
[1]Tse AN, et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res, 2007, 13 (2 Pt 1), 591-602.|[2]Dai Y, et al. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res, 2010, 16 (2), 376-383.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1; Chk2; PDGFR
Available Sizes
Frequently Asked Questions
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