CHIR-124

CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM.

Product Specifications

CAS Number

[405168-58-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Checkpoint Kinase (Chk) ; FLT3; PDGFR

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CHIR-124.html

Purity

99.05

Solubility

DMSO : 7.14 mg/mL (ultrasonic)

Smiles

ClC1=CC2=C(NC(C(C3=NC4=C(C=CC=C4)N3)=C2N[C@@H]5CN6CCC5CC6)=O)C=C1

Molecular Formula

C23H22ClN5O

Molecular Weight

419.91

Precautions

H302

References & Citations

[1]Tse AN, et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res, 2007, 13 (2 Pt 1), 591-602.|[2]Dai Y, et al. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res, 2010, 16 (2), 376-383.