PF-06815345 (hydrochloride)
Product Specifications
UNSPSC Description
PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13.4 μM. PF-06815345 hydrochloride significantly decreases the PCSK9 level in vivo in mouse[1][2].
Target Antigen
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pf-06815345-hydrochloride.html
Purity
98.15
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N([C@H]1CNCCC1)C2=C(Cl)C=CC=N2)C3=CC=C(C4=C(C5=NN=NN5[C@H](C)OC(OCC)=O)N(C)N=C4)C(F)=C3.[H]Cl
Molecular Weight
634.49
References & Citations
[1]Akin A, et al. Overcoming the Challenges of Making a Single Enantiomer N-1 Substituted Tetrazole Prodrug Using a Tin-Mediated Alkylation and Enzymatic Resolution[J]. Organic Process Research & Development, 2019, 23(6): 1167-1177. |[2]Darout E, et al. Preparation of substituted amide compounds as PCSK9 inhibitors: Canada, CA2907071 A1 2016-04-08.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112598A/PF-06815345-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112598A/PF-06815345-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
2334434-49-8
Available Sizes
Curated Selection
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