Forodesine
Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels[1][2].
Product Specifications
CAS Number
209799-67-7
Product Name Alternative
BCX-1777; Immucillin-H
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Forodesine.html
Purity
99.10
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(NC=C2[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)=C2NC=N1
Molecular Formula
C11H14N4O4
Molecular Weight
266.25
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
PAX8 (Renal Cell Marker) (PAX8/2774R), CF488A conjugate, 0.1mg/mL
TACSTD2 / TROP2 (Epithelial Marker) (TACSTD2/2153), CF594 conjugate, 0.1mg/mL
MAGE A1 (MA454), CF640R conjugate, 0.1mg/mL
