Forodesine

Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels[1][2].

Product Specifications

CAS Number

[209799-67-7]

Product Name Alternative

BCX-1777; Immucillin-H

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Forodesine.html

Purity

99.10

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(NC=C2[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)=C2NC=N1

Molecular Formula

C11H14N4O4

Molecular Weight

266.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895.|[2]Bantia S, et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H) --a novel potent and orally active immunosuppressive agent. Int Immunopharmacol. 2001 Jun;1 (6) :1199-210.