DC-SX029
Product Specifications
UNSPSC Description
DC-SX029 is a potent SNX10 protein-protein interaction (PPI) inhibitor with oral activity with an estimated KD constant of ~0.935 μM by surface plasmon resonance (SPR). DC-SX029 blocks the SNX10-PIKfyve interaction, thereby decreased the TBK1/c-Rel signaling activation. DC-SX029 does not affect the protein level of SNX10. DC-SX029 has the potential for inflammatory bowel disease (IBD) research[1][2].
Target Antigen
IKK; NF-κB; PIKfyve
Type
Reference compound
Related Pathways
NF-κB;PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dc-sx029.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(S(=O)(NCC(C(F)(F)F)CCC(O)=O)=O)C=C1)OC
Molecular Weight
398.35
References & Citations
[1]Weilian Bao, et al. Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation. Pharmacol Res. 2021 Jul:169:105679.|[2]Weilian Bao, et al. Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells. Sci Adv. 2023 Sep;9(35):eadh5016.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160477/DC-SX029-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160477/DC-SX029-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
300713-88-6
Available Sizes
Curated Selection
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