MK-4101
Product Specifications
UNSPSC Description
MK-4101 is a Smoothened (SMO) antagonist (IC50 of 1.1 μM for 293 cells ) and also a potent inhibitor of the hedgehog pathway (IC50 of 1.5 μM for mouse cells; IC50 of 1 μM for KYSE180 oesophageal cancer cells). MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis[1].
Target Antigen
Apoptosis; Hedgehog; Smo
Type
Reference compound
Related Pathways
Apoptosis;Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MK-4101.html
Purity
98.23
Solubility
DMSO : ≥ 50 mg/mL
Smiles
FC(C1=CC=CC=C1C2=NN=C(C34CCC(C5=NOC(C6CC(F)(F)C6)=N5)(CC4)CC3)N2C)(F)F
Molecular Weight
493.47
References & Citations
[1]Filocamo G et al. MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.
Mol Cancer Ther. 2016 Jun;15(6):1177-89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100036/MK-4101-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100036/MK-4101-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
935273-79-3
Available Sizes
Curated Selection
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