MS4322 (isomer)

MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092) ; Blue: E3 ligase ligand HY-112078) ; Black: linker (HY-124780) ; E3+linker (HY-173093) ) [1].

Product Specifications

CAS Number

[2601727-80-2]

Product Name Alternative

YS43-22 (isomer)

UNSPSC

12352005

Target

Histone Methyltransferase; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms4322-isomer.html

Purity

95.32

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1CC(C1)NC2=NC=NC(C(NC[C@H](O)CN3CC4=CC=CC=C4CC3)=O)=C2)COCCOCCOCCOCCOCC(N[C@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O

Molecular Formula

C55H76N10O12S

Molecular Weight

1101.32

References & Citations

[1]Shen Y, et al. Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. J Med Chem. 2020 Sep 10;63 (17) :9977-9989.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon; DOT1L; EHMT1/GLP/KMT1D; EHMT2/G9a/KMT1C; EZH1; EZH2; MDM2; NSD2/MMSET/WHSC1; PRMT1; PRMT3; PRMT4; PRMT5; PRMT6; PRMT7; PRMT8; SETD2/KMT3A; SETD7/KMT7; SETD8/KMT5A; SETDB1/KMT2G; SMYD2; SMYD3; SUV39H2/KMT1B; von Hippel-Lindau (VHL)