ALPK1-IN-1
Product Specifications
CAS Number
2765457-72-3
UNSPSC Description
ALPK1-IN-1 (Compound A001) is a potent inhibitor of alpha-kinase 1 (ALPK1). ALPK1 is an intracytoplasmic serine threonine protein kinase that plays an important role in activating the innate immune response to bacteria via TRAF-interacting protein with forkhead-associated domain (TIFA) dependent proinflammatory NF-κB signaling[1].
Target Antigen
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Infection
Assay Protocol
https://www.medchemexpress.com/alpk1-in-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C=C1)C(C)(C2=CSC(NC(NC(C3=CN=C(C=C3)N4CCNCC4)C)=O)=N2)C
Molecular Weight
480.63
References & Citations
[1]Danyang Liu, et al. Alpha protein kinase 1 inhibitors and methods of use. WO2022063152A1.
Shipping Conditions
Room Temperature
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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