Aconine
Aconine inhibits receptor activator of nuclear factor (NF) -κB ligand (RANKL) -induced NF-κB activation.
Product Specifications
CAS Number
[509-20-6]
Product Name Alternative
Jesaconine
UNSPSC
12352005
Hazard Statement
H300+H330
Target
NF-κB
Type
Natural Products
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Aconine.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@H]1C[C@H](OC)[C@@]23[C@]([H])(C4)[C@]5([H])[C@@H](O)[C@@]4(O)[C@@H](OC)[C@H](O)[C@]5(O)[C@H]6[C@H](OC)[C@@]([H])2[C@]1(COC)CN(CC)[C@H]63
Molecular Formula
C25H41NO9
Molecular Weight
499.59
Precautions
H300+H330
References & Citations
[1]Zeng XZ, et al. Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression. Acta Pharmacol Sin. 2016 Feb;37 (2) :255-63.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NF-κB
Available Sizes
Curated Selection
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