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A3AR antagonist 3

A3AR antagonist 3 (compound 21) is a selective A3 adenosine receptor (A3AR) antagonist with a Ki of 37 nM. A3AR antagonist 3 shows >60-fold selectivity in comparison to A1 and A2A adenosine receptors[1].

Product Specifications

CAS Number

863202-33-9

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/a3ar-antagonist-3.html

Solubility

10 mM in DMSO

Smiles

[H][C@@]12[C@H]([C@@](C2)([H])CC1)NC3=C4N=CNC4=NC(NC5=CC=CC=C5)=N3

Molecular Formula

C17H18N6

Molecular Weight

306.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Melissa Perreira, et al. "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48 (15) :4910-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A3 receptor (A3R)

Available Sizes

Frequently Asked Questions

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