Blebbistatin
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration[1][2].
Product Specifications
CAS Number
[674289-55-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/blebbistatin.html
Purity
99.64
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C2(O)C(N(C3=CC=CC=C3)CC2)=NC4=C1C=C(C)C=C4
Molecular Formula
C18H16N2O2
Molecular Weight
292.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Ho WT, et al. Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics. J Mol Med (Berl) . 2019 Sep;97 (9) :1345-1357.|[2]Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25 (1) :24-38.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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