Blebbistatin

Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration[1][2].

Product Specifications

CAS Number

[674289-55-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Myosin

Type

Reference compound

Related Pathways

Cytoskeleton

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/blebbistatin.html

Purity

99.64

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C2(O)C(N(C3=CC=CC=C3)CC2)=NC4=C1C=C(C)C=C4

Molecular Formula

C18H16N2O2

Molecular Weight

292.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Ho WT, et al. Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics. J Mol Med (Berl) . 2019 Sep;97 (9) :1345-1357.|[2]Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25 (1) :24-38.