Anti-Mouse IL-6R Antibody (15A7)
Anti-Mouse IL-6R Antibody (15A7) is a rat-derived anti-mouse IL-6R IgG2b κ type antibody inhibitor. Anti-Mouse IL-6R Antibody (15A7) blocks IL-6 binding to IL-6Rα and inhibits both IL-6 classic and trans-signaling. Anti-Mouse IL-6R Antibody (15A7) can be used for the researches of cancer and inflammation, such as triple-negative breast cancer[1][2][3][4].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352203
Target
Interleukin Related
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-mouse-il-6r-antibody-15a7.html
Purity
98.47
Solubility
10 mM in DMSO
Smiles
[Anti-MouseIL-6RAntibody(15A7)]
Molecular Weight
(150 kDa)
References & Citations
[3]Farias-Jofre M, et al. Blockade of IL-6R prevents preterm birth and adverse neonatal outcomes. EBioMedicine. 2023 Dec;98:104865.|[4]By Anne Vink, et al. Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor. J . Exp. Med. Volume 172, Issue 3.|[1]Romano M, et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity. 1997 Mar;6 (3) :315-25. |[2]Haq ATA, et al. Immunotherapeutic IL-6R and targeting the MCT-1/IL-6/CXCL7/PD-L1 circuit prevent relapse and metastasis of triple-negative breast cancer. Theranostics. 2024 Mar 3;14 (5) :2167-2189.
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4°C for 2 years, do not freeze
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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