3MB-PP1

3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8) . 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM) . 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division[1][2][3].

Product Specifications

CAS Number

[956025-83-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

CDK; DAPK; Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/3mb-pp1.html

Concentration

10mM

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=C2C(N(C(C)(C)C)N=C2CC3=CC=CC(C)=C3)=NC=N1

Molecular Formula

C17H21N5

Molecular Weight

295.38

Precautions

H302, H315, H319

References & Citations

[1]Burkard ME, et al. Enabling and disabling polo-like kinase 1 inhibition through chemical genetics. ACS Chem Biol. 2012 Jun 15;7 (6) :978-81.|[2]Hollomon JM, et al. The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway. PLoS Genet. 2022;18 (1) :e1009622. Published 2022 Jan 4.|[3]Al-Ghabkari A, et al. Validation of chemical genetics for the study of zipper-interacting protein kinase signaling. Proteins. 2018 Nov;86 (11) :1211-1217.