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TBHQ (Standard)

TBHQ (Standard) is the analytical standard of TBHQ. This product is intended for research and analytical applications. TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX) -induced cardiotoxicity through activation of Nrf2[1]. TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC) -induced cell proliferation inhibitionin melanoma[2].

Product Specifications

CAS Number

1948-33-0

Product Name Alternative

Tert-Butylhydroquinone (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; ERK; Ferroptosis; Keap1-Nrf2; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Autophagy; MAPK/ERK Pathway; NF-κB; Others; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tbhq-standard.html

Purity

99.86

Solubility

DMSO : ≥ 56.66 mg/mL

Smiles

OC1=CC=C(O)C=C1C(C)(C)C

Molecular Formula

C10H14O2

Molecular Weight

166.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Lin-Feng Wang, et al. Tert-butylhydroquinone ameliorates doxorubicin-induced cardiotoxicity by activating Nrf2 and inducing the expression of its target genes. Am J Transl Res. 2015; 7 (10) : 1724–1735.|[2]Hu H, et al. Dehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1/2-ERK1/2 cascade in melanoma.Onco Targets Ther. 2019 Jul 2;12:5163-5175.|[3]XIAOJING SHI, et al. Tert-butylhydroquinone attenuates the ethanol-induced apoptosis of and activates the Nrf2 antioxidant defense pathway in H9c2 cardiomyocytes.Int J Mol Med. 2016 Jul; 38 (1) : 123–130.|[4]Sukumari-Ramesh S, et al. Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury AfterIntracerebral Hemorrhage in Mice.J Mol Neurosci. 2016 Apr;58 (4) :525-31.

Shipping Conditions

Room Temperature

Storage Conditions

4°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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