Hemiasterlin
Hemiasterlin ((-) -Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
157207-90-4
Product Name Alternative
(-) -Hemiasterlin; Milnamide B
UNSPSC
12352005
Target
ADC Payload
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hemiasterlin.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CN(C)C2=CC=CC=C12)C)=O)=O)=O
Molecular Formula
C30H46N4O4
Molecular Weight
526.71
References & Citations
[1]Jiraborrirak Charoenpattarapreeda, et al. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics. Angew Chem Int Ed Engl. 2020 Dec 14;59 (51) :23045-23050.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Pyrrolobenzodiazepines
Available Sizes
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