Hemiasterlin

Hemiasterlin ((-) -Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[157207-90-4]

Product Name Alternative

(-) -Hemiasterlin; Milnamide B

UNSPSC

12352005

Target

ADC Payload

Type

Natural Products

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hemiasterlin.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CN(C)C2=CC=CC=C12)C)=O)=O)=O

Molecular Formula

C30H46N4O4

Molecular Weight

526.71

References & Citations

[1]Jiraborrirak Charoenpattarapreeda, et al. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics. Angew Chem Int Ed Engl. 2020 Dec 14;59 (51) :23045-23050.