Hemiasterlin
Hemiasterlin ((-) -Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
157207-90-4
Product Name Alternative
(-) -Hemiasterlin; Milnamide B
UNSPSC
12352005
Target
ADC Payload
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hemiasterlin.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CN(C)C2=CC=CC=C12)C)=O)=O)=O
Molecular Formula
C30H46N4O4
Molecular Weight
526.71
References & Citations
[1]Jiraborrirak Charoenpattarapreeda, et al. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics. Angew Chem Int Ed Engl. 2020 Dec 14;59 (51) :23045-23050.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Pyrrolobenzodiazepines
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
AP52161PU-N 400 µL
TTC10 (IFT88) (C-term) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details 