W6134

W6134 is highly potent and selective RORγ covalent inhibitor with an IC50 of 0.21 μM. W6134 exhibits excellent selectivity for RORγ over RORα, RXRγ, and ERRγ. W6134 significantly inhibits RORγ transcriptional activity W6134 inhibits the proliferation and colony formation and induces apoptosis in castration-resistant prostate cancer cells (CRPC) . W6134 can be used for the research of castration-resistant prostate cancers (CRPC) [1].

Product Specifications

CAS Number

[2983540-55-0]

UNSPSC

12352005

Target

Apoptosis; ROR

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/w6134.html

Purity

99.90

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C2=C(C=CC=C2)NC(C=C)=O)C(Cl)=C1)CC3=CC=C(C=C3)S(=O)(CC)=O

Molecular Formula

C25H23ClN2O4S

Molecular Weight

482.98

References & Citations

[1]Fang W, et al. Discovery of the First-in-Class RORγ Covalent Inhibitors for Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2024 Jan 16.