W6134
W6134 is highly potent and selective RORγ covalent inhibitor with an IC50 of 0.21 μM. W6134 exhibits excellent selectivity for RORγ over RORα, RXRγ, and ERRγ. W6134 significantly inhibits RORγ transcriptional activity W6134 inhibits the proliferation and colony formation and induces apoptosis in castration-resistant prostate cancer cells (CRPC) . W6134 can be used for the research of castration-resistant prostate cancers (CRPC) [1].
Product Specifications
CAS Number
[2983540-55-0]
UNSPSC
12352005
Target
Apoptosis; ROR
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/w6134.html
Purity
99.90
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C2=C(C=CC=C2)NC(C=C)=O)C(Cl)=C1)CC3=CC=C(C=C3)S(=O)(CC)=O
Molecular Formula
C25H23ClN2O4S
Molecular Weight
482.98
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ
Available Sizes
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