SR1078

SR1078 is a selective agonist of retinoic acid receptor-related orphan receptor α/γ (RORα/RORγ) . SR1078 directly binds to the ligand binding domain of RORα and RORγ and increases the transcriptional activity of these receptors, leading to stimulation of RORα/γ target gene transcription[1][2].

Product Specifications

CAS Number

[1246525-60-9]

UNSPSC

12352005

Hazard Statement

H302

Target

ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SR1078.html

Purity

99.75

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C1)C2=CC=C(C(F)(F)F)C=C2

Molecular Formula

C17H10F9NO2

Molecular Weight

431.25

Precautions

H302

References & Citations

[1]Wang Y, et al. Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ. ACS Chem Biol. 2010 Nov 19;5 (11) :1029-34.|[2]Wang Y, Billon C, Walker JK, Burris TP. Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism. ACS Chem Neurosci. 2016;7 (2) :143-148.