PERK-IN-6
PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM[1].
Product Specifications
CAS Number
[1337532-14-5]
UNSPSC
12352005
Target
PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/perk-in-6.html
Purity
99.82
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CC1=NC(C)=CC=C1)N2C3=C(CC2)C=C(C4=CN(C)C5=C4C(N)=NC=N5)C=C3
Molecular Formula
C23H22N6O
Molecular Weight
398.46
References & Citations
[1]Axten JM, et al. Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development. ACS Med Chem Lett. 2013 Aug 12;4 (10) :964-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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