AIM-100

AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect[1][2].

Product Specifications

CAS Number

[873305-35-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ack1

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AIM-100.html

Purity

99.95

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C1(C2=C(C3=CC=CC=C3)OC4=C2C(NC[C@@H]5CCCO5)=NC=N4)=CC=CC=C1

Molecular Formula

C23H21N3O2

Molecular Weight

371.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Mahajan K, et al.  Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Am J Pathol. 2012 Apr;180 (4) :1386-93.|[2]Mahajan K, et al. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012 Jun 22;287 (26) :22112-22.|[3]Mahajan K, et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate. 2010 Sep 1;70 (12) :1274-85.