Fosaprepitant (dimeglumine)

Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052) . Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV) [1].

Product Specifications

CAS Number

[265121-04-8]

Product Name Alternative

MK-0517; L785298

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Fosaprepitant-dimeglumine.html

Purity

99.0

Solubility

10 mM in DMSO|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C1N=C(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@H](C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OCC2)NN1P(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC

Molecular Formula

C37H56F7N6O16P

Molecular Weight

1004.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Pranav Prasoon, et al. Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine-induced antinociception in rats. Indian J Pharmacol. 2016 Jul-Aug; 48 (4) : 394-398.